At the heart of the Seminary's main quadrangle is its center for worship, the Frank H. and Fannie W. Caldwell Chapel. The chapel was constructed under one major directive, that it "be the dominant symbol on the campus to clearly show that this is a theological seminary dedicated to the worship and service of God." Caldwell Chapel crowns the campus like a jewel.

Built in the style of Modern Interpretation of Perpendicular Gothic, the chapel's exterior is graced by a 65-foot campanile with an electronic carillon. Traditional and contemporary symbols of faith are blended together within the chapel. Its beautiful windows were designed by William Schickel of Loveland, Ohio, and its organ, designed in the historcial tracker fashion with more than 2,000 pipes, was a gift from Roger Wood Puckett.

In 1964 the chapel was named in honor of the Seminary's fourth president (1936-1954), Frank H. Caldwell, and his wife, Fannie, with deep appreciation for all that the Caldwells had done for the institution.